Selected Relevant References

  • Gabizon, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A. and Barenholz, Y., Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54, 987–992 (1994).
  • Haran, G., Cohen, R., Bar, L.K. and Barenholz, Y., Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim. Biophys. Acta 1151, 201–215 (1993).
  • Lasic, D.D., Frederik, P.M., Stuart, M.C.A., Barenholz, Y. and McIntosh, T.J., Gelation of liposome interior. A novel method for drug encapsulation. FEBS Lett. 312, 255–258 (1992)
  • Gabizon, A., Shmeeda, H. and Barenholz, Y., Pharmacokinetics of pegylated liposomal Doxorubicin: Review of animal and human studies. Clin. Pharmacokinetics 42, 419–436 (2003).
  • Barenholz, Y., Doxil® – The First FDA-approved nano-drug: Lessons learned. J. Control. Release 160 (2), 117-134 (2012).
  • Silverman, L. and Barenholz, Y., In vitro experiments showing enhanced release of doxorubicin from Doxil in the presence of ammonia may explain drug release at tumor site. Nanomedicine: Nanotechnol. Biol. Med. (2015) 11, 1841–1850.
  • Wei, X, Cohen R. and Barenholz Y., Insights into composition/structure/ function relationships of Doxil ® gained from “high-sensitivity” differential scanning calorimetry, European Journal of Pharmaceutics and Biopharmaceutics (2016) 104, 260–270
  • Schilt, Y., Berman, T., Wei, X., Barenholz, Y. and Raviv, U., Using solution x-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs. Biochimica et Biophysica Acta 1860, 108–119 (2016).
  • Wei X., Shamrakov D., Nudelman S., Peretz- Damari S., Nativ-Roth E., Regev O. and Barenholz Y., Cardinal Role of Intraliposome Doxorubicin-Sulfate Nanorod Crysta in Doxil Properties and Performance. ACS Omega, 3 , 2018, 2508-2517